World J Nephrol Urol

World Journal of Nephrology and Urology, ISSN 1927-1239 print, 1927-1247 online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Nephrol Urol and Elmer Press Inc

Journal website http://www.wjnu.org

Original Article

Volume 1, Number 2-3, June 2012, pages 51-58

Factors Associated With Fibrate-Induced Creatinine Elevation: Observations in an Outpatient Setting

Figure

Figure 1. Mean change in creatinine seen within significantly associated factors.

Tables

**Table 1.** Pre and Post-Fibrate Treatment Creatinine Values Amongst Patients Stratified by Different Characteristics
	Pre Treatement Creatinine (µmol/L)					Post Treatement Creatinine (µmol/L)				Paired t test
	n	Mean	sd	Min / Max	Median	Mean	sd	Min / Max	Median	P
Total	132	81.9	17.3	33 / 127	83.0	93.8	20.4	52 / 143	91.0	0.0001
Male	92	85.7	17.2	33 / 127	85.5	99.6	19.0	70 / 143	97.0	0.0001
Female	40	73.2	14.1	35 / 106	73.5	80.5	17.2	52 / 128	82.0	0.0026
Diabetic	34	82.1	14.1	59 / 121	85.0	89.2	18.0	53 / 139	88.0	0.0004
Non-Diabetic	97	81.9	18.4	33 / 127	83.0	95.4	21.1	52 / 143	93.0	0.0001
On statin treatment	58	80.6	16.8	33 / 117	82.0	90.4	16.8	53 / 141	87.5	0.0001
Not on statin treatment	74	83.0	17.7	33 / 127	83.0	96.5	22.6	52 / 143	93.0	0.0001

**Table 2.** Model 1: Association Between Change in Creatinine Concentration (Dependent Variable) and Baseline Factors (Independent Variable) Studied Using Separate Linear Regression Analyses; Model 2: Multiple Regression Analysis With Change in Creatinine (Dependent Variable) and Changes in Lipid Values (Independent Variables). Analysis Corrected for Duration of Fibrate Treatement
	N	coefficient	95% Confidence Interval	P
Model 1
Male	132	6.64	1.0 / 12.3	0.022
Pre treatement Creatinine	132	-0.20	-0.3 / -0.1	0.011
Age	129	0.04	-0.3 / 0.2	0.782
Diabetes	131	-6.37	-12.4 / -0.4	0.037
Duration of treatment	124	1.70	-6.5 / 3.1	0.482
Statin treatment	132	-3.78	-9.1 / 1.5	0.16
Model 2
Change in TC levels	109	0.54	-1.68 / 2.77	0.63
Change in TG levels	109	-1.37	-2.43 / -0.32	-0.011
Change in HDL-C levels	109	-6.53	-6.30 / 19.36	0.32