| World Journal of Nephrology and Urology, ISSN 1927-1239 print, 1927-1247 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, World J Nephrol Urol and Elmer Press Inc |
| Journal website http://www.wjnu.org |
Review
Volume 8, Number 1, March 2019, pages 8-13
Methicillin-Resistant Staphylococcus aureus Infections in Patients With Renal Disorders: A Review
Tables
| Children < 2 years and adults ≥ 65 years |
| Athletes |
| Injection drug users |
| Homosexuals |
| Military personnel |
| Inmates of correctional facilities, residential homes or shelters |
| Veterinarians, pet owners and pig farmers |
| Patients with post flu-like illness and/or severe pneumonia |
| Patients with concurrent skin and soft-tissue infections |
| History of colonization or recent infection with CA-MRSA |
| Available drugs | Limitations | Dose adjustment in renal patients |
|---|---|---|
| Vancomycin | MIC creep, hVISA development, variable tissue penetration, and potential for nephrotoxicity at higher concentrations and in combination with other nephrotoxic agents | Yes |
| Daptomycin | Potential for decreased susceptibility with increased vancomycin MIC and hVISA | Yes |
| Linezolid | Multiple potentially serious side effects (marrow suppression, lactic acidosis, peripheral and optic neuropathy, and serotonin syndrome), especially with prolonged use | No |
| Tigecycline | Low serum levels with limited efficacy in bacteremia, black box warning from the US Food and Drug Administration (FDA) for all-cause mortality | No |