Association of Vitamin D With Prostate Carcinoma: A Single Institutional Observational Study

Surya Kant Choubey, Gotam Pipara, Saurabh Mittal


Background: Recent studies highlight a role for vitamin D (VD) in the growth and differentiation of various cell types. The biologically active form of vitamin D3 is 1,25-dihydroxyvitamin D3. Most cells of the body including prostate cells have vitamin D receptor (VDR) and VD metabolizing enzymes, and can respond to 1,25-VD. Literature supports multipronged effects of 1,25-VD in the prevention of prostate carcinoma development and progression. However, the relationship between prostate carcinoma and VD is still not entirely understood. There are no studies conducted on the association of VD and prostate carcinoma among the Asian population and our study is the first of its kind in literature and hence the need for the same.

Methods: All men more than 50 years of age who presented to our hospital between July 2015 and July 2017 with lower urinary tract symptom (LUTS), and had a suspicious digital rectal examination (DRE) and hypoechoic areas on transrectal ultrasound (TRUS), were considered for the study. Those patients whose biopsies came as malignancy were taken as study subjects and patients with a negative biopsy were taken as controls. VD and serum prostatic-specific antigen (PSA) was done for all patients undergoing biopsy.

Results: Eighty-six men underwent prostate biopsy for suspicious DRE with hypoechoic areas on TRUS. Out of the 86 men, 66 men had a positive histopathology, suggestive of adenocarcinoma of the prostate gland (group A), and the remaining 20 men (group B) had a negative biopsy. All patients diagnosed with malignancy had severe VD deficiency and was found to be statistically significant.

Conclusion: VD deficiency is a risk factor for development of prostate carcinoma and there is a strong correlation between them. Further trials are however required to study the effect of VD supplementation on the natural course of the disease.

World J Nephrol Urol. 2017;6(3-4):21-24



Vitamin D deficiency; Carcinoma prostate; Calcitriol

Full Text: HTML PDF
Home     |     Log In     |      About     |      Search     |      Current     |      Archives     |      Submit      |     Subscribe



Aims and Scope

Current Issues

Conflict of Interest

About Publisher

Editorial Board



Company Profile

Editorial Office

Misconduct and Retraction


Company Registration

Contact Us

Abstracting and Indexing



Instructions to Authors


Declaration of Helsinki

Contact Publisher

Submission Checklist


Terms of Use

Company Address

Submit a Manuscript

Open Access Policy

Privacy Policy

Browse Journals

Publishing Fee

Publishing Policy


Recent Highlights

Peer-Review Process

Publishing Quality

Code of Ethics

Advertising Policy

Manuscript Tracking

Advanced Search

For Librarians


Publishing Process

Publication Frequency

For Reviewers

Propose a New Journal


World Journal of Nephrology and Urology, quarterly, ISSN 1927-1239 (print), 1927-1247 (online), published by Elmer Press Inc.        
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada
© Elmer Press Inc. All Rights Reserved.