Microbiology Risk Factors and Outcomes of Peritonitis in Tunisian Peritoneal Dialysis Patients

Lilia Ben Lasfar, Yosra Guedri, Awatef Azzebi, Wissal Sahtout, Sinda Mrabet, Asma Fradi, Salma Toumi, Ferdaous Sabri, Samira Ben Amor, Dorsaf Zallema, Abdellatif Achour

Abstract


Background: Peritonitis is a major complication of peritoneal dialysis (PD), accounting for considerable mortality and hospitalization among PD patients. We have performed a single unit study examining rate of peritonitis, causative organisms, clinical outcomes and impact on technique failure and patient survival.

Methods: It was a retrospective review of the medical records of 182 PD patients who were followed up from January 2006 through June 2016. We have listed 186 episodes of peritonitis.

Results: The overall incidence of peritonitis during the 10-year study period was one episode every 27.25 month-patient. The mean time to first peritonitis after beginning PD was 14.25 ± 16 months (0 - 65). Gram-positive organisms were the main implicated agents and caused 27.92% of peritonitis. In multivariate Cox regression, no correlation was associated with diabetes, cardiovascular disease and residual renal function at baseline. In the Kaplan-Meier analysis, the peritonitis group was not correlated with more loss of residual renal function. More dropouts from PD were observed compared to the peritonitis-free group (P < 0.000), but no influence with patient survival.

Conclusion: Gram-positive organisms were the main causative agents. And peritonitis was associated to technique failure but not with patient survival.Z




World J Nephrol Urol. 2018;7(2):45-52
doi: https://doi.org/10.14740/wjnu349w


Keywords


Peritonitis; Risk factor; Technique survival; Patient survival

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