Cancer Antigen 125 and Nephrotic Syndrome

Edwin Rolando Castillo Velarde

Abstract


Background: Cancer antigen 125 (CA-125) serves as a nonspecific test for the diagnosis of several pathologic conditions involving a compromised mesothelium resulting from inflammatory processes. This investigation reports the association of CA-125 with severe nephrotic syndrome caused by primary glomerulopathy, which often coexists with inflammation.

Methods: CA-125 levels, clinical data and isolated ultrafiltration therapy were assessed with severe nephrotic syndrome. Nineteen patients were recruited with nephrotic syndrome and primary glomerulopathy. Of these, seven patients had criteria for severe nephrotic syndrome which was defined as including all three of the following criteria: 1) proteinuria is greater than or equal to 8 g/24 h; 2) the presence of anasarca; and 3) creatinine is greater than or equal to 1.2 mg/dL. The nonparametric Spearman Rho and Kruskal-Wallis tests were used to assess these correlations.

Results: There was an increase in CA-125 levels in 85% of the patients with nephrotic syndrome. The patients defined as having severe nephrotic syndrome showed a median CA-125 value of 1,501 U/mL (P < 0.001), with levels up to 90-fold greater than normal during the initial assessment. CA-125 ? 700 U/mL was associated with 100% sensitivity and 91% specificity for severe nephrotic syndrome (P < 0.001).

Conclusions: CA-125 test is associated quantitatively with the severity of nephrotic syndrome.




World J Nephrol Urol. 2019;8(1):14-16
doi: https://doi.org/10.14740/wjnu385


Keywords


CA-125; Nephrotic syndrome; Isolated ultrafiltration therapy

Full Text: HTML PDF
 

Browse  Journals  

     

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

World Journal of Nephrology and Urology, quarterly, ISSN 1927-1239 (print), 1927-1247 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.wjnu.org   editorial contact: editor@wjnu.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada
© Elmer Press Inc. All Rights Reserved.